Cedrus atlantica (Endl.) Manetti ex Carrière Essential Oil Alleviates Pain and Inflammation with No Toxicity in Rodent

Cedrus atlantica (Endl.) Manetti ex Carrière is an endemic tree with spiritual value, and it was used since immemorial time in folk medicine. The present study aims to evaluate the anti-inflammatory (carrageenan-induced paw edema formalin tests) analgesic effects (hot plate acetic acid writhing of cedarwood essential oil, as well inspect any toxicity (acute toxicity), using several vivo assays. Following test hot test, EO presented excellent effect compared controls, especially dose 50 mg/kg. Similar results were found while assessing potential carrageenan-induced acute assessment subsequent monitoring animals, biochemical analysis, relative organ weight, demonstrated a total safety EO. GC/MS analysis composition revealed that major compounds contained this are beta-himachalene (51.95%), followed by alpha-himachalene (15.82%), gamma-himachalene (12.15%). This supports usage alleviate pain inflammation.